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Potentials and a variety of slow potentials 97 ACTION POTENTIALS IN ELECTRICALLY EXCITABLE CELLS During paxforex minimum deposit, ion channels open and close and a few ions flow Gating mechanisms for Na and K channels in the axolemma are 98 98 voltage-dependent 98 The action potential paxforex minimum deposit propagated by local spread of depolarization 99 Membranes at nodes of Ranvier have high concentrations of Na channels 99 FUNCTIONAL PROPERTIES OF VOLTAGE-GATED ION CHANNELS 99 Ion channels are macromolecular complexes that form aqueous pores in the lipid membrane 99 Voltage-dependent gating requires voltage-dependent conformational changes in the protein component(s) of ion channels 100 Pharmacological agents acting on ion channels help define their functions 101 THE VOLTAGE-GATED ION CHANNEL SUPERFAMILY 101 Na channels were identified by neurotoxin labeling and their primary structures were established by cDNA cloning 101 Ca2 channels have a structure similar to Na channels 103 Voltage-gated K channels were identified by genetic means 103 Inwardly rectifying K channels were cloned by expression methods THE MOLECULAR BASIS FOR ION CHANNEL FUNCTION 103 We begin to know structural determinants of the ion selectivity filter and pore 103 Voltage-dependent activation requires moving charges 105 The fast inactivation gate is on the inside 106 ION CHANNEL DIVERSITY 107 Na channels are primarily a single family 107 Three subfamilies of Ca2 channels serve distinct functions 107 There are many families of K channels 107 Basic Neurochemistry: Molecular, Cellular and Medical Aspects 0-12-088397-X 103 95 708 Chapter 21 Alternating Current Circuits and Electromagnetic Waves JAMES CLERK MAXWELL, Scottish Theoretical Physicist (1831 1879) Maxwell developed the electromagnetic theory of light, the kinetic theory of gases, and explained the nature of Saturns rings and color vision.

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